Similar to Hanna-Barbera’s successful Scooby-Doo, Where Are You!, Goober and the Ghost Chasers also features a group of teenagers solving spooky mysteries with their dog Goober. The Ghost Chasers use their equipment from the Apparition Kit (like the Specter Detector, the Poltergeist Powder, etc.) when it comes to determining whether the ghost is real or not. The major differences were that the ghosts they eventually find are real and would help in defeating the fake ghosts. Some of those people behind the mask of some fake ghosts are not criminals. Goober had the power to become invisible when he was scared by ghosts and his closest human companion is reckless instead of cowardly. Also unlike Scooby-Doo, Goober can talk more clearly.
In eight of the first 11 episodes, the Partridge Kids were regular members of the cast, with their live-action counterparts voicing the parts. They disappear after the eleventh episode and did not appear when other guest stars appeared.